Managing IBS

 

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Start by consulting with a physician to discuss an IBS management program that may include IBgard. IBgard utilizes breakthrough science via SST® (Site Specific Targeting). This technology delivers microspheres of peppermint oil (in a solid state), along with fiber and amino acids (from gelatin protein), quickly and reliably where they are needed the most in IBS – predominantly in the small intestine. IBgard helps normalize the lining of the gut (gut mucosal barrier) and localized immune activation,1 and thus helps normalize the digestion and absorption of food nutrients.

IBgard is the only peppermint oil formulated into tiny microspheres to help deliver product quickly and reliably to the lower gut. Besides efficacy, this SST technology minimizes the potential for heartburn and anal burning,* which are a common side effects among older delivery technologies for peppermint oil. In a recent randomized, multi-centered, double-blind, placebo-controlled trial, IBgard was shown to start working in as early as 24 hours, and this benefit grew when measured at four weeks.§ No heartburn or anal burning was seen with IBgard in this study. This study was peer-reviewed and published in a distinguished medical journal in Feb. 2016.§2 IBgard showed efficacy in 1-2 hours, in a real-world patient-reported outcomes trial, IBSACTTM, published in a peer-reviewed journal.§

IBgard should be taken as directed by a physician. The usual adult dosage is: 1-2 capsules, as needed, up to three time a day. Take at least 30 minutes before or after a meal, with water. Do not exceed eight capsules per day. Swallow capsules whole or mix microspheres with applesauce. Do not chew. Note: Many physicians are now recommending taking IBgard before a meal, as it enables the supportive effect of IBgard to start as early as possible.

Like all medical foods regulated under section 5(b) the Orphan Drug Act (21 U.S.C. [360ee](b)(3)), IBgard should be given only to patients receiving active medical supervision for their IBS. A physician should provide an IBS management program and instructions for use of IBgard. Once a program is in place, be sure to follow up with a physician to monitor progress and adjust the program as needed.

The IBgard Difference

IBgard Overview

IBgard is a medical food specially formulated for the dietary management of IBS. IBgard capsules contain individually triple-coated, sustained-release microspheres of Ultramen®, an ultrapurified peppermint oil along with fiber and amino acids (from gelatin protein). In a 2016 peer-reviewed and published clinical study,§ IBgard has been shown to start working in as early as 24 hours.* IBgard showed efficacy in 1-2 hours, in a real-world patient-reported outcomes trial, IBSACTTM, published in a peer-reviewed journal.§

IBgard can help to...

  • Normalize the digestion and absorption of food nutrients that have been compromised by IBS.3
  • Manage the accompanying and often distressing group of symptoms of IBS. These include, at varying times, abdominal pain, discomfort or cramping, bloating or gas, diarrhea, constipation, or bouts of diarrhea interrupted by constipation, urgency of bowel movement, sense of an incomplete bowel movement and pain during bowel movement.4
  • Promote bacterial balance in the small intestine.5
IBgard Caplet with Microspheres

In addition to peppermint oil, each IBgard serving of 2 capsules provides approximately 640 mg of fiber and approximately 400 mg of amino acids (from gelatin protein). These, too, are intended to help toward normalizing the lining of the gut (gut mucosal barrier) and localized immune activation.1 The l-Menthol in peppermint oil has anti-inflammatory,6 antispasmodic,7 and visceral analgesic properties.8

IBgard Site Specific Targeting Technology Animation

The IBgard Difference - Advanced Science

Peppermint oil and its principal component, l-Menthol, has a history of effectiveness in IBS. However, until recently, its targeted delivery to the small intestine had posed a challenge. IBgard utilizes breakthrough science via SST® (Site Specific Targeting). This technology delivers microspheres of peppermint oil (in a solid state), along with fiber and amino acids (from gelatin protein), quickly and reliably where they are needed the most in IBS – predominantly in the small intestine. Besides helping manage IBS symptoms, this is important as 90 to 95% of nutrient absorption occurs in the small intestine.9 IBgard helps normalize the lining of the gut (gut mucosal barrier) and localized immune activation,1 and thus helps normalize the digestion and absorption of food nutrients.

Why Targeting the Small Intestine is So Important

The symptoms of IBS often occur within 90 minutes of meals.10 This reflects the time it takes for food to reach the small intestine. Recent scientific and clinical evidence points to the small intestine as the site of the disruption in the lining of the gut (gut mucosal) barrier and where transit time can also be disrupted.1 Thus, food can move too fast or too slow, causing diarrhea, constipation or bouts of diarrhea interrupted by constipation. This is also the site where abdominal pain originates, probably from irritated nerve endings in the gut or from trapped gas. Only IBgard utilizes SST® (Site Specific Targeting) technology to deliver its ingredients to the small intestine. IBgard has been specially formulated so that it can be taken 30 minutes before or after meals to provide its calming properties. Note: Many physicians are now recommending taking IBgard before a meal, as it enables the supportive effect of IBgard to start as early as possible.

1 González-Castro, Ana M, Cristina Martínez, Eloísa Salvo-Romero, Marina Fortea, Cristina Pardo-Camacho, Teresa Pérez-Berezo, Carmen Alonso-Cotoner, Javier Santos, and María Vicario. 2016. “Mucosal Pathobiology and Molecular Signature of Epithelial Barrier Dysfunction in the Small Intestine in Irritable Bowel Syndrome.” Journal of Gastroenterology and Hepatology, 53–63. doi:10.1111/jgh.13417.

2 Cash, Brooks D., Michael S. Epstein, and Syed M. Shah. 2016. “A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms.” Digestive Diseases and Sciences 61 (2). Springer US: 560–71. doi:10.1007/s10620-015-3858-7.

3 Cash, Brooks, Michael Epstein, and Syed Shah. 2017. “In Patients with Irritable Bowel Syndrome-Mixed (IBS-M), a Novel Peppermint Oil Formulation Designed for Site Specific Targeting (PO-SST) in the Small Intestine Improves the 8 Symptoms That Comprise the Total IBS Symptoms Score (TISS).” In Digestive Disease Week. Chicago, IL.

4 Drossman, Douglas A., Lin Chang, Susan Schneck, Carlar Blackman, William F. Norton, and Nancy J. Norton. 2009. “A Focus Group Assessment of Patient Perspectives on Irritable Bowel Syndrome and Illness Severity.” Digestive Diseases and Sciences 54 (7): 1532–41. doi:10.1007/s10620-009-0792-6.

5 Goerg, K.J. et al., Aliment Pharmacol Ther 2003; 17:445-451.

6 Juergens, UR, M Stober, and H Vetter. 1998. European Journal of Medical Research 3 (12): 539–45.

7 Hawthron M et al (1988): Aliment Pharmacol Ther. 2(2):101-18.

8 Liu, Boyia; Fan, Lua; Balakrishna, Shrilathaa; Sui, Aiweia; Morris, John B.b; Jordt, Sven‐Erica,* Pain: October 2013 - Volume 154 - Issue 10 - p 2169–2177. doi: 10.1016/j.pain.2013.06.043.

9 Hawrelak, J.A. et al,. Alternative Medicine Review Vol 14, #4 2009, pg. 380-384.

10 Ragnarsson, Gudmundur, and Göran Bodemar. 1998. “Pain Is Temporally Related to Eating but Not to Defaecation in the Irritable Bowel Syndrome (IBS): Patients’ Description of Diarrhoea, Constipation and Symptom Variation during a Prospective 6-Week Study.” European Journal of Gastroenterology and Hepathology 10 (5): 415–21.

For more information on IBgard®, visit the Frequently Asked Questions Page

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